Precision-Engineered Nanocrystalline Silver

At FeynMed Solutions, our innovation is built on a proprietary physical vapour deposition (PVD) process that produces highly active nanocrystalline silver. This advanced technique allows us to create nanomaterials with controlled structural organization, defect density, grain size, and percentage of intergrain or intercrystal atoms (grain boundary atoms) — key features behind our platform’s unique biological performance.

WHY PHYSICAL VAPOUR DEPOSITION?

Unlike conventional chemical synthesis methods, our physical vapour deposition approach creates highly controlled nanocrystalline silver films and powders without the need for stabilizing surfactants or binders that can interfere with therapeutic function. This clean synthesis method enables:

Consistent nanostructure: Controlled crystal size and high concentration of grain boundaries that directly influence biological activity.
Tunable properties: The ability to customize formulations to balance antimicrobial and anti-inflammatory effects for specific clinical applications.
Enhanced purity and safety: A surfactant-free process that minimizes residual impurities, improving biocompatibility.

Unique Advantages of Our Nanocrystalline Silver

Multi-modal activity: Releases Ag⁰-containing clusters, Ag⁺, and higher oxidation state silver species in a sustained manner, which we anticipate will provide simultaneous antimicrobial, antiviral, and anti-inflammatory effects.
Localized delivery: Reduces reliance on systemic antibiotics and corticosteroids, helping to combat antimicrobial resistance (AMR) and minimize side effects.
Versatile formulations: Adaptable to a wide range of delivery modes, including wound dressings, bladder instillations, ophthalmic drops, and nebulized pulmonary treatments.

Applications Across Medicine

Our platform is uniquely positioned to address diverse, high-impact clinical needs. We anticipate it may be applicable in the following areas:

Wound and burn care: Medical device for rapid infection control.
Abdominal adhesions: Treatments delivered intraperitoneally to prevent post-surgical infection and adhesions.
Pulmonary infections: Nebulized formulations for targeted respiratory therapy.
Urinary tract infections: Bladder instillation to treat infections and reduce chronic inflammation.
Ocular diseases: Topical drops for infection and trauma-induced ocular inflammation.

MADE IN ALBERTA, CANADA

Our nanomaterials will be manufactured at our Edmonton facility, where rigorous quality systems ensure consistency. This local capability with scalability will enable us to move seamlessly from innovation to production of advanced nanotherapeutics that are anticipated to set new standards for infection and inflammation care worldwide.

ADDRESSING ANTIMICROBIAL RESISTANCE

We believe that our nanocrystalline silver technology will help address the global crisis of antimicrobial resistance (AMR) by providing a localized alternative to systemic antibiotics, reducing selective pressure that drives resistant strains.

NANOCRYSTALLINE SILVER VS. EXISTING SILVER AGENTS

Unlike silver nitrate, silver sulfadiazine (SSD), and other silver treatments which primarily release Ag⁺ and can cause cytotoxicity or delayed healing, our nanocrystalline silver releases a spectrum of Ag⁰-containing clusters, Ag⁺, and higher oxidation state silver. This is expected to enhance anti-microbial & anti-inflammatory activity while minimizing tissue irritation.

NANO-CRYSTALLINE
SILVER PEER REVIEWED RESEARCH

Overview

Pletts MW, Burrell RE. Clinically relevant evaluation of the antimicrobial and anti-inflammatory properties of nanocrystalline and nanomolecular silver. Wound Rep Reg. 2025;33(1):e13249. doi:10.1111/wrr.13249.

Sweet HM, Nadworny PL, Fung S, Wright JB, Burrell RE. Chapter 13. Silver nanostructures in medicine: Synthesis and biological activity. In: Grumezescu AM (Ed.), Antimicrobial nanoarchitectonics: From synthesis to applications, 2017, Elsevier, Cambridge, MA, pp. 358-382.

Antimicrobial Action

Wright, J. B., Lam, K., Hansen, D., & Burrell, R. E. (1999). Efficacy of topical silver against fungal burn wound pathogens. American journal of infection control, 27(4), 344-350.

Cavanagh MH, Burrell RE, Nadworny PL. Evaluating antimicrobial efficacy of new commercially available silver dressings. International Wound Journal 2010, 7(5):394-405.

Landry BK, Nadworny PL, Omotoso O, Maham Y, Burrell JC, Burrell RE. The kinetics of thermal instability in nanocrystalline silver and the effect of heat treatment on the antibacterial activity of nanocrystalline silver dressings. Biomaterials 2009;30:6929-6939.

Taylor PL, Ussher AL, Burrell RE. The impact of heat on nanocrystalline silver dressings. Part I: Chemical and biological properties. Biomaterials 2005;26:7221-7229.

Taylor PL, Omotoso O, Wiskel JB, Mitlin D, Burrell RE. The impact of heat on nanocrystalline silver dressings. Part II: Physical properties. Biomaterials 2005; 26:7230-7240.

Gallant-Behm CL, Yin HQ, Liu SJ, Heggers JP, Langford RE, Olson ME, et al. Comparison of in vitro disc diffusion and time kill-kinetic assays for the evaluation of antimicrobial wound dressing efficacy. Wound Repair and Regeneration. 2005;13(4):412-21.

Hatch KKA, Burrell RE, Ward CN. Effect of a novel sputtering process on the chemical and biological properties of silver-gold alloys. Int Wound J. 2024;21(3):e14475.

Anti-inflammatory Properties

Wright, J. B., Lam, K., Buret, A. G., Olson, M. E., & Burrell, R. E. (2002). Early healing events in a porcine model of contaminated wounds: effects of nanocrystalline silver on matrix metalloproteinases, cell apoptosis, and healing. Wound Repair and Regeneration, 10(3), 141-151.

Cavanagh MH, Burrell RE, Nadworny PL. Evaluating antimicrobial efficacy of new commercially available silver dressings. International Wound Journal 2010, 7(5):394-405.

Landry BK, Nadworny PL, Omotoso O, Maham Y, Burrell JC, Burrell RE. The kinetics of thermal instability in nanocrystalline silver and the effect of heat treatment on the antibacterial activity of nanocrystalline silver dressings. Biomaterials 2009;30:6929-6939.

Taylor PL, Ussher AL, Burrell RE. The impact of heat on nanocrystalline silver dressings. Part I: Chemical and biological properties. Biomaterials 2005;26:7221-7229.

Taylor PL, Omotoso O, Wiskel JB, Mitlin D, Burrell RE. The impact of heat on nanocrystalline silver dressings. Part II: Physical properties. Biomaterials 2005; 26:7230-7240.

Gallant-Behm CL, Yin HQ, Liu SJ, Heggers JP, Langford RE, Olson ME, et al. Comparison of in vitro disc diffusion and time kill-kinetic assays for the evaluation of antimicrobial wound dressing efficacy. Wound Repair and Regeneration. 2005;13(4):412-21.

Hatch KKA, Burrell RE, Ward CN. Effect of a novel sputtering process on the chemical and biological properties of silver-gold alloys. Int Wound J. 2024;21(3):e14475.

Antiviral Action

Nadworny, P. L., Hickerson, W. L., Holley-Harrison, H. D., Bloom, D. C., Grams, T. R., Edwards, T. G., ... & Burrell, R. E. (2023). Treatment of infection and inflammation associated with COVID-19, multi-drug resistant pneumonia and fungal sinusitis by nebulizing a nanosilver solution. Nanomedicine: Nanotechnology, Biology and Medicine, 48, 102654.